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Upwards of 15% of infertile men
have normal semen analysis results. A more thorough evaluation of sperm health is
A high DNA
fragmentation index (DFI) — the percentage of your sperm containing damaged DNA — is associated
conventional semen analysis gives you the basics: your sperm count, concentration, motility
(movement), and morphology (shape).
Pairing this info with your DFI provides the best picture of your fertility, how to improve
your chances of conception, and how to choose the right fertility treatment for you and your
Sperm DNA fragmentation analysis is included as part of our Forever package. You can
also purchase it as a standalone addition to your Standard Semen Analysis semen analysis.
Legacy’s labs use sperm chromatin dispersion
(SCD), a well-established technique for identifying sperm DNA damage.
During this test, sperm are carefully denatured and proteins are removed. Normal spermatozoa
can then be identified by their glowing “halos,” formed by loops of DNA at the head of the
sperm. These halos will not be present in sperm with highly damaged DNA. This allows lab
experts to visualize and quantify the percentage—or index—of sperm that contain DNA
A typical sperm DNA fragmentation analysis
costs $500 or more, and requires a trip to a lab to produce a fresh semen sample. Just as with
our semen analysis, Legacy offers the option to collect your sample at home, mail it in, and get
a clinic-grade DNA fragmentation report, for a fraction of the cost.