Semen Analysis with DNA Fragmentation Testing
At a glance:
A clinically validated option for DNA fragmentation testing
Measures the percentage of sperm that contain fragmented or damaged genetic information, in addition to standard parameters (count, motility, morphology)
Our mail-in kit means you can test from home instead of the clinic "collection room" — it's faster, more comfortable, and no time off work required
HSA/FSA eligible
How it works
Produce your sample at home. Use the prepaid label to ship it overnight to our full-service andrology lab.
We assess your concentration (how many sperm), motility (how they’re swimming), and morphology (how many are the correct shape), plus sperm DNA fragmentation (optional).
Your digital client dashboard includes more than just the numbers — it offers comprehensive info on what those numbers really mean, and how you can improve your chances of success.
We’re in this together. When you test with Legacy, you have access to a team of fertility specialists who can help you interpret your results and give you actionable next steps.
What does this test measure?
how much semen you produce
Volume
Semen plays a crucial role in carrying sperm through the reproductive tract. Producing the right amount means giving sperm the best chance at reaching the egg for fertilization.
How mANY sperm
Concentration
Sperm concentration is the number of sperm per milliliter of semen, as measured by a computer-assisted semen analysis device. We can use your sperm concentration and your semen volume to determine your total sperm count.
How many of your sperm are moving
Motility
Motility is the percentage of your sperm that are moving properly. In order to fertilize an egg, your sperm must be “swimming,” so motility is an important parameter for fertility.
Our report breaks down the number of sperm with progressive motility — moving forward or in large circles — vs. sperm that are swimming in tight circles, known as non-progressive motility.
Total number of moving sperm in your sample
Total motile sperm count
This metric is a calculation that includes sperm volume, concentration, and motility.
Because this parameter represents multiple sperm quality metrics, it's the best number we have to help us understand overall fertility and chances of conceiving with or without medical intervention.
How many of your sperm are the proper size and shape
Morphology
Morphology is the percentage of sperm that are normally shaped. A sperm’s structure affects its ability to reach and fertilize an egg, and abnormalities may indicate poor sperm development or genetic issues.
Fun fact: most sperm are abnormally shaped. Morphology as low as 4–14% is totally normal.
How many of your sperm contain damaged dna
DNA fragmentation index
The integrity of the DNA carried by sperm is an important factor in your ability to create a healthy pregnancy. and child. Age, illness, and lifestyle factors can cause damage this genetic material, called DNA fragmentation. This test measures the percentage of your sperm that contain damaged or fragmented DNA.
Sperm DNA fragmentation testing is not included as part of a routine semen analysis, but even those with normal results on a standard analysis may have elevated DNA fragmentation.
Legacy offers the only clinically validated at-home option for DNA fragmentation testing.
Other sperm testing & freezing options
Basic semen analysis
Best for:
- Proactive planning
- Trying to conceive without risk factors
- Understanding the impact of medication or treatment
Semen volume
Sperm concentration
Motility
Total motile sperm count
Morphology
Annual sperm freezing plan
Best for:
- Trying to conceive
- Infertility treatment
- Short-term planning
1 year of storage for 1 sample (renewable)
1 collection kit
5-year sperm freezing plan
Best for:
- Pre-vasectomy
- Military deployment
- Before testosterone therapy
5 years of storage for 2 samples (renewable)
2 collection kits
Pre-freeze STI test
25-year sperm freezing plan
Best for:
- Before medical treatment
- Pre-gender transition
- Long-term planning
25 years of storage for 3 samples
3 collection kits
Pre-freeze STI test
Advanced fertility testing