Kartagener’s syndrome is a rare autosomal or “single gene” genetic disorder, and is a type of primary ciliary dyskenesia. In other words, the flagella and cilia \u2014 finger-like projections on the outside of cells \u2014 do not move as they should. This disorder is characterized by the mirror-image reversal of internal organs (situs invertus totalis) and can lead to neonatal respiratory distress; frequent lung, sinus, and ear infections; and infertility.<\/p>\n\n\n\n
Kartagener\u2019s syndrome is a rare autosomal or \u201csingle gene<\/a>\u201d recessive genetic disorder. This condition is a type of primary ciliary dyskinesia, a disorder in which the hair-like structures on the outside of a cell \u2014 which normally help it move \u2014 are dysfunctional. Kartagener\u2019s syndrome can cause infertility in all sexes. In people with testes<\/a>, the flagella \u2014 also known as the \u201cmoving tails\u201d \u2014 of sperm can be directly affected by Kallmann\u2019s syndrome. In people with ovaries, Kallmann\u2019s syndrome causes impaired ciliar mobility in the lining of the fallopian tubes, contributing to infertility. Those with this condition may have to consider alternatives to conceive, including assisted reproductive technology (ART) <\/a>procedures.<\/p>\n\n\n\n Similar to Kallmann syndrome,<\/a> Kartagener\u2019s syndrome is also caused by mutations to certain genes. Studies have shown<\/a> that mutations on genes DNAH5 and DNA11, on bands 5p15.1 and 9p13.3, cause primary ciliary dyskinesia. <\/p>\n\n\n\n As Kartagener\u2019s syndrome is a genetic disorder, people with this disorder must have inherited a mutated gene from both of their parents.<\/p>\n\n\n\n There is currently no known cure for Kartagener\u2019s syndrome. As a result, doctors will typically prescribe patients medications and treatments to minimize the symptoms of this disorder, including lung, sinus, and ear infections. Long-term antibiotics are also used to help reduce the impact of respiratory issues. Treatment varies from patient to patient, but typically features some form of airway clearance and low-dose antibiotics.<\/p>\n\n\n\n Fertility treatments for Kartagener\u2019s syndrome patients include IVF<\/a> with ICSI<\/a>.<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"template":"glossary","glossary-cat":[],"class_list":["post-5504","glossary","type-glossary","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.givelegacy.com\/vnext\/index.php?rest_route=\/wp\/v2\/glossary\/5504"}],"collection":[{"href":"https:\/\/www.givelegacy.com\/vnext\/index.php?rest_route=\/wp\/v2\/glossary"}],"about":[{"href":"https:\/\/www.givelegacy.com\/vnext\/index.php?rest_route=\/wp\/v2\/types\/glossary"}],"author":[{"embeddable":true,"href":"https:\/\/www.givelegacy.com\/vnext\/index.php?rest_route=\/wp\/v2\/users\/4"}],"version-history":[{"count":1,"href":"https:\/\/www.givelegacy.com\/vnext\/index.php?rest_route=\/wp\/v2\/glossary\/5504\/revisions"}],"predecessor-version":[{"id":17200,"href":"https:\/\/www.givelegacy.com\/vnext\/index.php?rest_route=\/wp\/v2\/glossary\/5504\/revisions\/17200"}],"wp:attachment":[{"href":"https:\/\/www.givelegacy.com\/vnext\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5504"}],"wp:term":[{"taxonomy":"glossary-cat","embeddable":true,"href":"https:\/\/www.givelegacy.com\/vnext\/index.php?rest_route=%2Fwp%2Fv2%2Fglossary-cat&post=5504"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Kartagener\u2019s syndrome causes abnormalities in the respiratory tract, including neonatal respiratory problems and frequent lung, sinus, ear infections. That\u2019s because cilia are responsible for moving mucus out of the airways; without functioning cilia, mucus accumulates unchecked. Because the flagella, or tail, of the sperm<\/a> is related to cilia, Kartagener\u2019s can lead to infertility<\/a> as a result of poor sperm motility<\/a> (movement). It\u2019s also characterized by the mirror-image reversal of internal organs, also known as \u201csitus invertus totalis.\u201d<\/p>\n\n\n\nKartegener\u2019s syndrome and fertility<\/h2>\n\n\n\n
Causes of Kartegener\u2019s syndrome<\/h2>\n\n\n\n
Treatment of Kartegener\u2019s syndrome<\/h2>\n\n\n\n